VIPER , a peptide derived from vaccinia protein A 46 , specifically inhibits TLR 4 by directly targetting Mal and TRAM
نویسندگان
چکیده
Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2; Opsona Therapeutics Ltd, Trinity Centre for Health Sciences, Institute of Molecular Medicine, St James's Hospital, Dublin 8, Ireland. Department of Infectious Diseases and Immunology, University of Massachusetts; Medical School, Worcester, MA 01605; Department of Biochemistry, University of Cambridge, Cambridge, UK.
منابع مشابه
TRAM Is Involved in IL-18 Signaling and Functions as a Sorting Adaptor for MyD88
MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced by another TIR domain-containing adaptor, Mal/TIRAP, which brings MyD88 to the plasma membrane and promotes its interaction with the cytosolic...
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Signaling by two of the most important bacteria-sensing TLRs, TLR2 and TLR4, involves two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-beta (Trif)-related adaptor molecule (TRAM). Recently, new insights into the functioning of these two adapters have emerged. Mal is required by both TLRs to act as a bridge to recruit the adaptor ...
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تاریخ انتشار 2014